IN THE SPOTLIGHT Mitochondrial One-Carbon Metabolism Maintains Redox Balance during Hypoxia
نویسندگان
چکیده
Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Corresponding Author: Navdeep S. Chandel, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611. Phone: 312-503-2549; Fax: 312-503-0411; E-mail: [email protected] doi: 10.1158/2159-8290.CD-14-1228 ©2014 American Association for Cancer Research. Summary: Mitochondria generate high levels of reactive oxygen species (ROS) to activate protumorigenic signaling pathways. In parallel, the mitochondria must also increase their antioxidant capacity to lower ROS levels and prevent cancer cell death. In this issue of Cancer Discovery , Ye and colleagues demonstrate that serine catabolism through one-carbon metabolism within the mitochondrial matrix is necessary to maintain this redox balance. Cancer Discov; 4(12); 1371–3. ©2014 AACR.
منابع مشابه
Mitochondrial one-carbon metabolism maintains redox balance during hypoxia.
Mitochondria generate high levels of reactive oxygen species (ROS) to activate protumorigenic signaling pathways. In parallel, the mitochondria must also increase their antioxidant capacity to lower ROS levels and prevent cancer cell death. In this issue of Cancer Discovery, Ye and colleagues demonstrate that serine catabolism through one-carbon metabolism within the mitochondrial matrix is nec...
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